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    • 专利摘要:
    The present disclosure relates to the technical field of Fricke gel dosimeter, in particular to a three-dimensional Fricke gel dosimeter, its method of preparation and application. To determine the radiation dose accurately, Fricke dosimeters are often used to measure the radiation dose. The present disclosure provides a personalized and personified three-dimensional Fricke gel dosimeter, which collects the exposure site information of the based patient and achieves a phantom by means of 3D printing, in order to provide assay results with highest precision for individuals.
    公开号:BE1027235B1
    申请号:E20205597
    申请日:2020-08-27
    公开日:2021-08-19
    发明作者:Depeng Ma；Jianfeng Qiu；Li Pei
    申请人:Shandong First Medical Univ & Shandong Academy Of Medical Sciences；
    IPC主号:
    专利说明:

    Fricke three-dimensional gel dosimeter, method of preparation and application BE2020 / 5597
    TECHNICAL FIELD The present disclosure relates to the technical field of the Fricke gel dosimeter, in particular a three-dimensional Fricke gel dosimeter, its method of preparation and application.
    TECHNICAL BACKGROUND The information on the technical background site of this disclosure is provided only to better understand the general context of this disclosure and should not necessarily be taken as an acknowledgment or suggestion in any form that such information constitutes a site. of the existing art already known to those skilled in the art. In clinical treatments, medical personnel must control the radiation dose precisely during radiation therapy, in order to reduce the impact of radiation on normal tissue. Existing control methods include such as one-time dose validation, area dose validation, three-dimensional dose validation, in particular the ionization chamber film, the semiconductor array, the ionization chamber matrix , gel dosimeter, etc. Among them, three-dimensional dose validation, which allows the dose to be displayed at any point in the target area at one time and validate the three-dimensional dose distribution, is widely used in the field of radiation dosing. A gel dosimeter is a radiation dosimetry phantom that consists of a support made of material equivalent to human body tissue and a radiation sensitive compound of uniform distribution. It combines two functions, the tissue equivalent phantom function and the dosimeter function, to record the three-dimensional distribution of a radiation field without inserting a detector into the gel. It is a dose validation device with broad application prospects. The Fricke three-dimensional gel dosimeter is a gel dosimeter commonly used in the art, in which, a solution of ferrous sulfate (ie Fricke's solution) is BE2020 / 597 combined with a gel, and Fe * is converted to Fe * under the action of rays (X or Y rays). Xylenol orange, as a chelator, is added to the phantom and combines selectively and specifically with Fe3 +, which reduces the oxidation-reduction potential, promotes the conversion of Fe " and to strengthen the coloring. Fe ** and xylenol orange are as a yellow complex in an acidic environment, and after exposure, the Fe * and xylenol orange complex will turn orange-violet. Within a certain range, the conversion efficiency of Fe ”* is proportional to the level of radiation. Since the phantom exhibits a different color distribution after exposure, it is possible to observe the varying depth of the phantom and the spatial distribution of dose at the different positions. However, the inventor has discovered in research that the individual patient has unique characteristics, differing in the position and type of the lesion, and that existing dosimeters cannot validate the dosing plan for individuals. DESCRIPTION OF THE INVENTION Based on the above technical background, the present disclosure provides a three-dimensional Fricke gel dosimeter. It consists of making a 3D printing from the medical image data of a patient to obtain a mold of the site of the patient undergoing radiation therapy; and pouring in a mixture comprising a fabric equivalent material (gel, polyvinyl chloride (PVC), polyvinyl alcohol (PVA), etc.), ferrous ammonium sulfate, sodium chloride, sodium orange. xylenol and sulfuric acid in a mold, and validate the dose by observing the change in color of the phantom and the conversion of Fe * to Fe *. According to the first aspect of the present disclosure, a three-dimensional Fricke gel dosimeter is provided, which consists of the following components: a hollow mold, water, tissue equivalent material, ferrous ammonium sulfate, sodium chloride , xylenol orange and sulfuric acid.
    Preferably, the tissue equivalent material comprises polysaccharide, gelatin, PVC, PVA, agarose or gellan gum. BE2020 / 5597 In particular, the tissue equivalent material is a tissue equivalent material whose CT value is pocket of that of the human tissue to be tested and must be selected according to the human tissue to be tested.
    Preferably, the mass ratio of water, tissue equivalent material, ferrous ammonium sulfate, sodium chloride, xylenol orange and sulfuric acid is: 100: (0.3 - 10) : (0.01 - 1): (0.001 - 0.1): (0.001 - 0.15): (0.05 - 5). According to a second aspect of the present disclosure, a method for preparing the Fricke three-dimensional gel dosimeter according to the first aspect is provided, which comprises the following steps: (1) printing a profile mold of the exposure site; (2) pour a solution obtained by mixing water, fabric equivalent material, ferrous ammonium sulfate, sodium chloride, xylenol orange and sulfuric acid in a certain ratio into a hollow mold and let it cool to form a gel.
    Preferably, step (1) comprises the following operations: obtaining information on the patient's exposure site profile by computed tomography (CT) or magnetic resonance imaging (MRI), and printing a hollow mold to profile of said site with a 3D printer.
    The hollow mold and its material depend on the fabric equivalent material, for example, a high temperature fabric equivalent material corresponds to a high temperature resistant material and a low temperature fabric equivalent material corresponds to a conventional material.
    Preferably, the preparation in step (2) is as follows: mix xylenol orange, ferrous ammonium sulfate, sodium chloride and sulfuric acid in a certain ratio to obtain a solution, and add the tissue equivalent material in water and dissolve to obtain solution B, mix solution A and solution B to obtain mixed solution and pour the mixed solution into the mold and allow it to cool to form a gel.
    Preferably, the gel is prepared 10 to 14 hours before use.
    Preferably, the cooled gel is stored at 5-7 ° C. BE20205597 According to a fourth aspect of the present disclosure, a three-dimensional Fricke gel dosimeter prepared according to the third aspect is provided. According to a fifth aspect of the present disclosure, applications of the Fricke three-dimensional gel dosimeter according to the fourth aspect in the field of radiation dosing are provided. Compared with the existing techniques, the present disclosure exhibits the following beneficial effects: The present disclosure provides a three-dimensional Fricke gel dosimeter based on 3D printing, which allows to simulate the information on the patient's exposure site profile based on 3D printing, in order to obtain dosing results with higher precision for individuals.
    EMBODIMENTS It should be noted that the detailed description below is only illustrative in order to better understand the present disclosure. It should be noted that, unless otherwise indicated, all technical and scientific terms used in this disclosure have the same meaning as those well known to those skilled in the art. It should be noted that the terms used here are intended to describe embodiments only, instead of limiting the embodiment. Unless otherwise indicated, the singular form includes the plural, furthermore, the words used herein "include" and / or "include", indicate the presence of the characteristic, step, work, device, component and / or the combination of these. Like the description in the technical background above, to solve the problems in the existing art, the present disclosure provides a three-dimensional Fricke phantom, method of preparation and application. The technical solution of this disclosure will be described in more detail below via the exemplary embodiments, so that those skilled in the art can better understand the technical solution of the present disclosure. Example 1
    1. Print a three-dimensional radiotherapy site mold BE2020 / 5597 Print with a multi-injector 3D printer for multi-materials. Print the organs to be treated with radiotherapy at corresponding sizes according to the individual body. 5 (1) CT or MRI: Obtain a three-dimensional profile of the organ or tissue by imaging. (2) Printing: printing a profile mold of the organ with a 3D printer.
    2. Fill the mold with tissue equivalent to human organ The material equivalent to human tissue includes polysaccharide, gelatin, PVC, PVA, agar, agarose or gellan gum. Using agarose as an example: Materials: distilled water, ferrous ammonium sulfate, sodium chloride, sulfuric acid, agarose, and xylenol orange. Preparation: 800 ml of distilled water Ferrous ammonium sulfate 0.3136 g Sodium chloride 0.0468 g Xylenol orange 0.0608 g Sulfuric acid 3.999 g Agarose 8 g The process: (1) add xylenol orange , ferrous ammonium sulfate, sodium chloride and sulfuric acid in 25% (V / V) of the total water, and mix to obtain a solution; (2) add the weighed agarose to the remaining water, and heat with stirring until a clear and transparent solution is obtained, namely solution B; (3) measure the temperature of solution B, when the temperature reaches 60 - 70 ° C, add solution A, and mix solution A and solution B with stirring; (4) Fill the organ profile mold with the mixed solution of solution A and solution B, let it cool to form a gel to a certain hardness, and take it out of the mold to finally get a three-dimensional dosimeter Fricke custom gel.
    3. Validate the radiotherapy dose BE2020 / 5597 (1) Expose the phantom with Co-60. Scan the gel phantom and transfer the scan result as a standard phantom to a planning system, transfer a radiation therapy plan from the patient to the standard phantom, and calculate the dose. (2) Perform a radiotherapy plan on the phantom and obtain a three-dimensional dose distribution of the phantom at the end of the scan. (3) Compare the results of the design with the color of the phantom and the distribution of Fe +, If the difference between the two is within an acceptable error range, the plan is considered feasible and the plan will be implemented on the patient, otherwise the causes should be investigated and the plan corrected for revalidation .
    The examples below are given only by way of example preferably, rather than limiting the present disclosure, and modifications and variations on the present disclosure by those skilled in the art are of course possible.
    All modifications, replacements and equivalent improvements which respect the spirit and principles of this disclosure must be included within the scope of the protection of this disclosure.
    权利要求:
    Claims (10)
    [1]
    1. Fricke three-dimensional gel dosimeter, characterized in that it consists of the following components: a hollow mold, water, tissue equivalent material, ferrous ammonium sulfate, sodium chloride, xylenol and sulfuric acid.
    [2]
    2. Fricke three-dimensional gel dosimeter according to claim 1, characterized in that the tissue equivalent material comprises polysaccharide, gelatin, PVC, PVA, agarose or gellan gum.
    [3]
    3. Fricke three-dimensional gel dosimeter according to claim 1, characterized in that the mass ratio between water, tissue equivalent material, ferrous ammonium sulfate, sodium chloride, xylenol orange and l sulfuric acid is: 100: (0.3 - 10): (0.01 - 1): (0.001 - 0.1): (0.001 - 0.15): (0.05 - 5).
    [4]
    4, Preparation process for the three-dimensional Fricke gel dosimeter according to any one of claims 1 to 3, characterized in that it comprises the following steps: (1) printing a profile mold of the exposure site; (2) pour a solution obtained by mixing water, fabric equivalent material, ferrous ammonium sulfate, sodium chloride, xylenol orange and sulfuric acid in a certain ratio into a hollow mold and let it cool to form a gel.
    [5]
    5. A method of preparing the three-dimensional Fricke gel dosimeter according to claim 4, characterized in that, step (1) comprises the following operations: obtaining information on the exposure site profile of the patient by the CT or the MRI, and print a hollow mold profile of said site with a 3D printer.
    [6]
    6. A method of preparing the three-dimensional Fricke gel dosimeter according to claim 4, characterized in that, step (2) comprises the following operations: mixing the xylenol orange, the ferrous ammonium sulfate, the sodium chloride and sulfuric acid in a certain ratio in 25% (V / V) of the total water to obtain solution A; add the material equivalent to fabric in water and dissolve,
    let swell to obtain solution B; mix solution A and solution B BE2020 / 5597 to obtain a mixed solution and pour the mixed solution into the mold and allow it to cool to form a gel.
    [7]
    7. Process for preparing the three-dimensional Fricke gel dosimeter according to claim 4, characterized in that the gel is prepared 10 to 14 hours before use.
    [8]
    8. A method of preparing the three-dimensional Fricke gel dosimeter according to claim 4, characterized in that the cooled gel is stored at 5-7 ° C.
    [9]
    9. A method of preparing the three-dimensional Fricke gel dosimeter according to any one of claims 4 to 6.
    [10]
    10. Applications of the three-dimensional Fricke gel dosimeter according to claim 9.
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    引用文献:
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    法律状态:
    2021-09-30| FG| Patent granted|Effective date: 20210819 |
    优先权:
    申请号 | 申请日 | 专利标题
    CN201911100683.7A|CN110818916A|2019-11-12|2019-11-12|Three-dimensional Fricke gel dosimeter, and preparation method and application thereof|
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